反应详情

6-Amino-9-benzyl-8-hydroxy-2-mercaptopurine (110 mg, 0.40 mmol) was suspended in dimethylformamide (10 ml). To the suspension were added potassium carbonate (50 mg, 0.40 mmol) and 2-phthalimidoethyl bromide (108 mg, 0.40 mmol) in order. The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo, water and methanol were added to the residue, and the resulting crystals were taken by filtration to give the subject compound (138 mg, yield 75%).

1. customThe solvent was removed in vacuo, water and methanol
2. additionwere added to the residue
3. filtrationthe resulting crystals were taken by filtration