Hydrochloric Acid → HCID 178509055, compound

HRID 2269032Notes

Reaction equation

HRID 2269032 reaction equation
[OH-].[Na+].[NH2:3][C:4]1[N:12]=[C:11]([S:13][CH2:14][C:15]([O:17]C)=[O:16])[N:10]=[C:9]2[C:5]=1[N:6]=[C:7]([OH:26])[N:8]2[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.Cl>CO>[NH2:3][C:4]1[N:12]=[C:11]([S:13][CH2:14][C:15]([OH:17])=[O:16])[N:10]=[C:9]2[C:5]=1[N:6]=[C:7]([OH:26])[N:8]2[CH2:19][C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178501888HCID 178501888, compound

Product 1

HCID 178509055HCID 178509055, compoundYield 52%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a methanol solution (5 ml) containing 500 mg of sodium hydroxide was added 6-amino-9-benzyl-8-hydroxy-2-(methoxycarbonylmethyl)thiopurine (64 mg, 0.19 mmol). The solution was refluxed under heating, neutralized with 2N hydrochloric acid, filtered and washed with water to give the subject compound (32 mg, yield 52%).

Workup

  1. temperatureThe solution was refluxed
  2. temperatureunder heating
  3. filtrationfiltered
  4. washwashed with water

Sources & evidence

ORD record
ord-a4b32f921f6e49d887c8fc8708e55a7b
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

Loading…