反应详情

Crude 6-amino-9-benzyl-8-hydroxy-2-mercaptopurine (134 mg, 0.49 mmol) was suspended in dimethylformamide (60 ml). To the suspension were added potassium carbonate (100 mg, 0.72 mmol) and cyclohexylmethyl bromide (0.1 ml, 0.7 mmol) in order. The mixture was stirred at room temperature for 9 hours. The solvent was removed in vacuo, and the residue was purified by silica gel chromatography (3% methanol/chloroform) to give the subject compound (93 mg, yield 51%).

1. customThe solvent was removed in vacuo
2. customthe residue was purified by silica gel chromatography (3% methanol/chloroform)