反应详情

Crude 6-amino-9-benzyl-8-hydroxy-2-mercaptopurine (134 mg, 0.49 mmol) was suspended in dimethylformamide (60 ml). To the suspension were added potassium carbonate (100 mg, 0.72 mmol) and 1-(3-chloropropyl)piperazine (179 mg, 0.73 mmol) in order. The mixture was stirred at room temperature for 2 hours. The solvent was removed in vacuo, and the residue was purified by silica gel chromatography (20% methanol/chloroform) to give the subject compound (10 mg, yield 5%).

1. customThe solvent was removed in vacuo
2. customthe residue was purified by silica gel chromatography (20% methanol/chloroform)