Ammonia → HCID 178495892, compound

HRID 2269064Notes

Reaction equation

HRID 2269064 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([NH:11][CH2:12][CH2:13][O:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:23]C)[N:6]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.N>Cl>[NH2:1][C:2]1[N:10]=[C:9]([NH:11][CH2:12][CH2:13][O:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:23])[N:6]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 18332727HCID 18332727, compound

Product 1

HCID 178495892HCID 178495892, compoundYield 73%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-9-benzyl-8-methoxy-2-(2-methoxyethyl)aminopurine (26 mg, 0.079 mmol) in concentrated hydrochloric acid (20 ml) was stirred at room temperature for 7 hours. The reaction mixture was made basic with 28% aqueous ammonia. The resulting crystals were filtered to give the subject compound (18 mg, yield 73%).

Workup

  1. filtrationThe resulting crystals were filtered

Sources & evidence

ORD record
ord-05315196605f4779800948249c9a06d2
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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