HCID 18332748, compound → HCID 178496194, compound

HRID 2269066Notes

Reaction equation

HRID 2269066 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][O:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:24]C)[N:6]2[CH2:16][C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1>Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][O:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:24])[N:6]2[CH2:16][C:17]1[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=1

Participants

3

Reactant 1

HCID 18332748HCID 18332748, compound

Product 1

HCID 178496194HCID 178496194, compoundYield 77.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-9-(4-fluorobenzyl)-8-methoxy-2-(2-methoxyethoxy)purine (49 mg, 0.14 mmol) in concentrated hydrochloric acid (20 ml) was stirred for 12 hours. The reaction mixture was evaporated in vacuo to dryness and then 28% aqueous ammonia was added thereto. The resulting crystals were filtered to give the subject compound (36 mg, yield 77%).

Workup

  1. customThe reaction mixture was evaporated in vacuo to dryness
  2. addition28% aqueous ammonia was added
  3. filtrationThe resulting crystals were filtered

Sources & evidence

ORD record
ord-4e64032beda84fd191842aa091deed96
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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