Ammonia → HCID 178508977, compound

HRID 2269068Notes

Reaction equation

HRID 2269068 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][OH:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:23]C)[N:6]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.N>Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][OH:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:23])[N:6]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 183327906-Amino-9-benzyl-2-(3-hydroxypropoxy)-8-methoxypurine

Product 1

HCID 178508977HCID 178508977, compoundYield 51%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-9-benzyl-2-(3-hydroxypropoxy)-8-methoxypurine (83 mg, 0.25 mmol) in concentrated hydrochloric acid (5 ml) was stirred at room temperature for 4 hours. The reaction mixture was neutralized with 28% aqueous ammonia and the resulting crystals were filtered and washed with water to give the subject compound (40 mg, yield 51%).

Workup

  1. filtrationthe resulting crystals were filtered
  2. washwashed with water

Sources & evidence

ORD record
ord-c3f16079a0c445ff8e00430a4c89f364
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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