6-Amino-9-benzyl-2-(4-hydroxybutoxy)-8-methoxypurine → HCID 178508972, compound

HRID 2269069Notes

Reaction equation

HRID 2269069 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][OH:16])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:24]C)[N:6]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1>Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][CH2:14][CH2:15][OH:16])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:24])[N:6]2[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

Participants

3

Reactant 1

HCID 183327246-Amino-9-benzyl-2-(4-hydroxybutoxy)-8-methoxypurine

Product 1

HCID 178508972HCID 178508972, compoundYield 73.2%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-9-benzyl-2-(4-hydroxybutoxy)-8-methoxypurine (114 mg, 0.332 mmol) in concentrated hydrochloric acid (20 ml) was stirred at room temperature for 12 hours. The reaction mixture was evaporated in vacuo to dryness and to the residue was added aqueous ammonia. The resulting crystals were filtered to give the subject compound (80 mg, yield 73%).

Workup

  1. customThe reaction mixture was evaporated in vacuo to dryness and to the residue
  2. additionwas added aqueous ammonia
  3. filtrationThe resulting crystals were filtered

Sources & evidence

ORD record
ord-dfc27cf75b974098aca2c753192da13c
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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