6-Amino-9-benzyl-8-methoxy-2-(2-methoxyethoxy)purine → HCID 178496186, compound

HRID 2269072Notes

Reaction equation

HRID 2269072 reaction equation
[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][O:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([O:23]C)[N:6]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>Cl>[NH2:1][C:2]1[N:10]=[C:9]([O:11][CH2:12][CH2:13][O:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([OH:23])[N:6]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

3

Reactant 1

HCID 112789046-Amino-9-benzyl-8-methoxy-2-(2-methoxyethoxy)purine

Product 1

HCID 178496186HCID 178496186, compoundYield 84.2%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

6-Amino-9-benzyl-8-methoxy-2-(2-methoxyethoxy)purine (21 mg, 0.064 mmol) in concentrated hydrochloric acid (20 ml) was stirred at room temperature for 5 hours. The reaction mixture was evaporated in vacuo to dryness and 28% aqueous ammonia was added to the residue. The resulting crystals were filtered and washed with water to give the subject compound (17 mg, yield 84%).

Workup

  1. customThe reaction mixture was evaporated in vacuo to dryness and 28% aqueous ammonia
  2. additionwas added to the residue
  3. filtrationThe resulting crystals were filtered
  4. washwashed with water

Sources & evidence

ORD record
ord-12280cda89df4007be713dc0890864f8
Source dataset
uspto-grants-2001_12
Patent number
US06329381B1

Reaction notes

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