反应详情

温度

100 °C

To DMF suspension (10 ml) containing sodium hydride (300 mg, 7.5 mmol, 60% in mineral oil) were added 3-methylbutane-1-thiol (1 ml, 8.0 mmol) and 6-amino-9-benzyl-2-chloropurine (200 mg, 0.77 mmol) in order. The mixture was stirred under heating at 100° C. for 2.5 hours. Brine was added thereto and the mixture was extracted with chloroform. The organic layer was dried on magnesium sulfate, filtered and the solvent in the filtrate was evaporated in vacuo. The residue was purified with silica gel chromatography (1% methanol/chloroform) to give the subject compound (120 mg, yield 48%).

1. extractionthe mixture was extracted with chloroform
2. customThe organic layer was dried on magnesium sulfate
3. filtrationfiltered
4. customthe solvent in the filtrate was evaporated in vacuo
5. customThe residue was purified with silica gel chromatography (1% methanol/chloroform)