Bromine → HCID 18332686, Verbindung

HRID 2269143Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 2269143
[NH2:1][C:2]1[N:10]=[C:9]([NH:11][CH2:12][CH2:13][O:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[CH:5][N:6]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1.[Br:23]Br.S([O-])([O-])(=O)=S.[Na+].[Na+]>C(Cl)Cl>[NH2:1][C:2]1[N:10]=[C:9]([NH:11][CH2:12][CH2:13][O:14][CH3:15])[N:8]=[C:7]2[C:3]=1[N:4]=[C:5]([Br:23])[N:6]2[CH2:16][C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Komponenten

5

Edukt 3

HCID 24408BromineHCID 24477Sodium ThiosulfateHCID 183327796-Amino-9-benzyl-2-(2-methoxyethyl)aminopurine

Produkt 1

HCID 18332686HCID 18332686, VerbindungAusbeute 80 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

6-Amino-9-benzyl-2-(2-methoxyethyl)aminopurine (70 mg, 0.24 mmol) and bromine (0.5 ml) were dissolved in methylene chloride (50 ml). The solution was stirred at room temperature for 1 hour. Aqueous sodium thiosulfate was added to the reaction mixture. The organic layer was separated, dried on sodium sulfate and concentrated in vacuo to dryness. The residue was purified with silica gel chromatography (1% methanol/chloroform) to give the subject compound (71 mg, yield 80%).

Aufarbeitung

  1. customThe organic layer was separated
  2. customdried on sodium sulfate
  3. concentrationconcentrated in vacuo to dryness
  4. customThe residue was purified with silica gel chromatography (1% methanol/chloroform)

Quellen und Nachweise

ORD-Eintrag
ord-106ad6d7d64940b4aa863d460446356a
Quelldatensatz
uspto-grants-2001_12
Patentnummer
US06329381B1

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