反应详情

温度

100 °C

To sodium hydride (600 mg, 15 mmol 60% in mineral oil) were added DMF (10 ml), 2-dimethylaminoethanethiol (1.3 g, 9.2 mmol) and 6-amino-9-benzyl-2-chloropurine (100 mg, 0.39 mmol) in order. The mixture was stirred at 100° C. for 10 hours. After addition of saturated brine the reaction mixture was extracted with chloroform and the organic layer was dried on magnesium sulfate and concentrated in vacuo to dryness. The residue was purified with silica gel chromatography (10% methanol/chloroform) to give the subject compound (24 mg, yield 21%).

1. extractionwas extracted with chloroform
2. customthe organic layer was dried on magnesium sulfate
3. concentrationconcentrated in vacuo to dryness
4. customThe residue was purified with silica gel chromatography (10% methanol/chloroform)