反应详情

温度

120 °C

To sodium (150 mg, 6.5 mmol) in 5 ml of 3-ethoxypropanol were added 6-amino-9-benzyl-2-chloropurine (500 mg, 1.93 mmol) and DMF (10 ml). The mixture was heated at 120° C. for 1 hour. The reaction mixture was concentrated in vacuo to dryness. To the residue was added water and the mixture was extracted with chloroform. The organic layer was dried on sodium sulfate and the solvent was removed. The residue was purified with silica gel chromatography (2% methanol/chloroform) to give the subject compound (481 mg, yield 76%).

1. concentrationThe reaction mixture was concentrated in vacuo to dryness
2. additionTo the residue was added water
3. extractionthe mixture was extracted with chloroform
4. customThe organic layer was dried on sodium sulfate
5. customthe solvent was removed
6. customThe residue was purified with silica gel chromatography (2% methanol/chloroform)