反应详情

温度

130 °C

Sodium (66 mg, 2.9 mmol) in 50 ml of 2-methoxyethanol was added 6-amino-9-benzyl-2-chloropurine (150 mg, 0.58 mmol) and DMF (10 ml). The mixture was heated at 130° C. for 6 hour. The reaction mixture was concentrated in vacuo to dryness. To the residue was added water and the mixture was extracted with chloroform. The organic layer was dried on sodium sulfate and concentrated in vacuo to dryness. The residue was purified with silica gel chromatography (3% methanol/chloroform) to give the subject compound (123 mg, yield 71%).

1. concentrationThe reaction mixture was concentrated in vacuo to dryness
2. additionTo the residue was added water
3. extractionthe mixture was extracted with chloroform
4. customThe organic layer was dried on sodium sulfate
5. concentrationconcentrated in vacuo to dryness
6. customThe residue was purified with silica gel chromatography (3% methanol/chloroform)