反应详情

温度

90 °C

A mixture of 1-(4-benzyloxy-benzenesulfonyl)-5-hydroxy-5-methyl-piperidine-2-carboxylic acid methyl ester (0.047 g, 0.11 mmol), p-toluenesulfonic acid (0.010 g, 0.05 mmol) and toluene (2.0 mL) was heated to 90° C. for 2 h. After cooling to room temperature, the mixture was diluted with ethyl acetate, washed with saturated aqueous NaHCO3, dried over Na2SO4, filtered and concentrated in vacuo, giving 0.035 g of 5-(4-Benzyloxy-benzenesulfonyl)-1-methyl-2-oxa-5-aza-bicyclo[2.2.2]octan-3-one as a colorless oil:

1. temperatureAfter cooling to room temperature
2. washwashed with saturated aqueous NaHCO3
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. concentrationconcentrated in vacuo