Sodium → HCID 70189343, compound

HRID 2269523Notes

Reaction equation

HRID 2269523 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH:8]([C:22]2[CH:27]=[CH:26][CH:25]=[C:24]([N+:28]([O-])=O)[CH:23]=2)[NH:9][C@@H:10]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=2)[CH3:11])=[CH:4][CH:3]=1.[Na]>O.O.O.O.O.O.[Ni](Cl)Cl>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH:8]([NH:9][C@@H:10]([C:12]2[C:21]3[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=3)[CH:15]=[CH:14][CH:13]=2)[CH3:11])[C:22]2[CH:23]=[C:24]([NH2:28])[CH:25]=[CH:26][CH:27]=2)=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 5360545SodiumHCID 70188140HCID 70188140, compound

Product 1

HCID 70189343HCID 70189343, compoundYield 89.6%

Reagents, catalysts & solvents 1

HCID 11791229Dichloronickel;hexahydrateCatalyst

Procedure

Following a procedure similar to that described in Example (1b), 5.38 g of N-[(4-fluorophenyl)-(3-nitrophenyl)methyl]-N-[(R)-1-(napthalen-1-yl)ethyl]amine [prepared as described in step (a) above], 6.39 g of nickel chloride hexahydrate and 2.03 g of sodium bobohydride were reacted and purified, to obtain 4.46 g of the title compound as a pale yellow oil.

Workup

  1. customwere reacted
  2. custompurified

Sources & evidence

ORD record
ord-3b66c67962d4451c9fb361d55cc8d20c
Source dataset
uspto-grants-2001_12
Patent number
US06329405B1

Reaction notes

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