Pyridine → Methyl 5,6-dihydro-2H-thiopyran-3-carboxylate

Temperature

0 °C

To a solution of 4.93 gm (0.0279 mole) of methyl tetrahydro-2H-thiopyran-4-hydroxy-3-carboxylate from part B in anhydrous methylene chloride (25 mL) was added 6.77 mL (0.0837 mole) anhydrous pyridine. The solution was cooled to 0° C., upon which was added 3.25 mL (0.0420 mole) methanesulfonyl chloride, dropwise via syringe. The solution was allowed to warm to room temperature and stirred under N2 for 7.5 hrs. The reaction was then cooled to 0° C. and an additional 0.648 mL (0.00837 mole) of methanesulfonyl chloride was added. The solution was stirred at room temperature an additional 16 hrs. upon which ethyl acetate (125 mL) was added. The organic layer was washed with dilute HCl, saturated sodium bicarbonate, and saturated sodium chloride, dried over magnesium sulfate, filtered, and concentrated in vacuo to give a mixture of the cis and trans mesylate and unreacted methanesulfonyl chloride. The crude mesylate mixture was dissolved in anhydrous methylene chloride (30 mL) upon which was added 12.68 mL (0.0911 mole) triethyl amine. The reaction was stirred under N2 for 7 hrs. upon which was added 8.5 mL (0.061 mole) triethyl amine and the solution stirred 17 more hrs. The organic layer was washed once with dilute acid and once with saturated sodium chloride, dried over magnesium sulfate, filtered, and concentrated in vacuo. The crude material was purified by flash chromatography on 300 gm silica gel with 4-25% ethyl acetate in hexane to give 2.76 gm (63%) of methyl 5,6-dihydro-2H-thiopyran-3-carboxylate as a clear oil; mass spectrum m/z=159 (CI,M+H)

1. temperatureto warm to room temperature
2. temperatureThe reaction was then cooled to 0° C.
3. stirringThe solution was stirred at room temperature an additional 16 hrs
4. washThe organic layer was washed with dilute HCl, saturated sodium bicarbonate, and saturated sodium chloride
5. dry with materialdried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated in vacuo
8. customto give
9. stirringThe reaction was stirred under N2 for 7 hrs
10. stirringthe solution stirred 17 more hrs
11. washThe organic layer was washed once
12. additionwith dilute acid
13. dry with materialonce with saturated sodium chloride, dried over magnesium sulfate
14. filtrationfiltered
15. concentrationconcentrated in vacuo
16. customThe crude material was purified by flash chromatography on 300 gm silica gel with 4-25% ethyl acetate in hexane

ORD record

ord-e40f5441ba584020b44d5234d5d3792d

Source dataset

uspto-grants-2001_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06329524B1