1-Hydroxybenzotriazole → HCID 101051613, compound

HRID 2269633Notes

Reaction equation

HRID 2269633 reaction equation
[N:1]1([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([OH:5])=O.[CH2:16]([NH2:21])[C:17]([CH3:20])([CH3:19])[CH3:18].C1C=CC2N(O)N=NC=2C=1.CCN=C=NCCCN(C)C.Cl>CN(C=O)C>[N:1]1([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:8][CH2:7][CH2:6][C@H:2]1[C:3]([NH:21][CH2:16][C:17]([CH3:20])([CH3:19])[CH3:18])=[O:5]

Participants

6

Reactant 4

HCID 757711-HydroxybenzotriazoleHCID 79882NeopentylamineHCID 850831,2-Pyrrolidinedicarboxylic acid, 1-(1,1-dimethylethyl) ester, (2S)-HCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Product 1

HCID 101051613HCID 101051613, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In a DMF solution containing 1.00 g of Boc-Pro-OH, 0.58 ml of neopentylamine, 0.71 g of HOBt and 1.06 g of EDC hydrochloride were added and the resultant mixture was stirred for 14 hr. The reaction mixture was treated similarly to that in Example 30 (Process 3) to give 605 mg of the title compound.

Workup

  1. additionwere added
  2. additionThe reaction mixture was treated similarly to that in Example 30 (Process 3)

Sources & evidence

ORD record
ord-2e2afb33694d4698981e403ccca95792
Source dataset
uspto-grants-2001_12
Patent number
US06329502B1

Reaction notes

Loading…