2-Amino-2-methyl-1-propanol → Boc-Thz-NH-C(CH3)2-CH2OH

HRID 2269643Notes

Reaction equation

HRID 2269643 reaction equation
[N:1]1([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:8][S:7][CH2:6][C@H:2]1[C:3]([OH:5])=O.[NH2:16][C:17]([CH3:21])([CH3:20])[CH2:18][OH:19].CCN=C=NCCCN(C)C.Cl>C(Cl)Cl>[N:1]1([C:9]([O:11][C:12]([CH3:15])([CH3:14])[CH3:13])=[O:10])[CH2:8][S:7][CH2:6][C@H:2]1[C:3]([NH:16][C:17]([CH2:18][OH:19])([CH3:21])[CH3:20])=[O:5]

Participants

5

Reactant 3

HCID 118072-Amino-2-methyl-1-propanolHCID 688405(4R)-3-[(tert-butoxy)carbonyl]-1,3-thiazolidine-4-carboxylic acidHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride

Product 1

HCID 131722959Boc-Thz-NH-C(CH3)2-CH2OH

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

In a methylene chloride solution containing 0.30 g of Boc-Thz-OH, 0.12 ml of 2-amino-2-methyl-1-propanol and 0.29 g of EDC hydrochloride were added and the resultant mixture was stirred for 14 hr. The reaction mixture was treated similarly to that in Example 33 (Process 3) to give 190 mg of the title compound.

Workup

  1. additionwere added
  2. additionThe reaction mixture was treated similarly to that in Example 33 (Process 3)

Sources & evidence

ORD record
ord-5affd29a943f47cc9e06d2085465b29d
Source dataset
uspto-grants-2001_12
Patent number
US06329502B1

Reaction notes

Loading…