HCID 178500755, compound → 3-(3,4-dimethyl-benzoyl)-7-fluoro-1H-quinolin-4-one

HRID 226966Notes

Reaction equation

HRID 226966 reaction equation
CO[C:3](=[O:24])[C:4]([C:14](=[O:23])[C:15]1[CH:20]=[CH:19][C:18]([CH3:21])=[C:17]([CH3:22])[CH:16]=1)=[CH:5][NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[C:9]([F:13])[CH:8]=1>C1(OC2C=CC=CC=2)C=CC=CC=1>[CH3:22][C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][C:18]=1[CH3:21])[C:14]([C:4]1[C:3](=[O:24])[C:12]2[C:7](=[CH:8][C:9]([F:13])=[CH:10][CH:11]=2)[NH:6][CH:5]=1)=[O:23]

Participants

3

Reactant 1

HCID 178500755HCID 178500755, compound

Product 1

HCID 577547943-(3,4-dimethyl-benzoyl)-7-fluoro-1H-quinolin-4-oneYield 79.8%

Reagents, catalysts & solvents 1

HCID 7583Diphenyl EtherSolvent

Procedure

Compound 3k was prepared following the procedure described in Step 2 of Example 5 using 1.19 g (3.64 mmol) of 2-(3,4-Dimethyl-benzoyl)-3-(3-fluoro-phenylamino)-acrylic acid methyl ester 2h and 30 mL of diphenyl ether to yield 0.858 g of 3-(3,4-dimethyl-benzoyl)-7-fluoro-1H-quinolin-4-one 3k as a brown solid.

Workup

  1. customCompound 3k was prepared

Sources & evidence

ORD record
ord-cc24c7b698c24ce3a98d2134a5e54928
Source dataset
uspto-grants-2009_07
Patent number
US07557213B2

Reaction notes

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