Calcium Chloride → 4-Piperazinyl-2,6-bis-hydroxymethyl pyridine

HRID 2269689Notes

Reaction equation

HRID 2269689 reaction equation
C([O:3][C:4]([C:6]1[CH:11]=[C:10]([N:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)[CH:9]=[C:8]([C:18](OCC)=[O:19])[N:7]=1)=O)C.[Cl-].[Cl-].[Ca+2]>C1COCC1>[N:12]1([C:10]2[CH:11]=[C:6]([CH2:4][OH:3])[N:7]=[C:8]([CH2:18][OH:19])[CH:9]=2)[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]1

Participants

4

Reactant 2

HCID 5284359Calcium ChlorideHCID 85702736Diethyl-4-piperazinyl-2,6-pyridinedicarboxylate

Product 1

HCID 212573294-Piperazinyl-2,6-bis-hydroxymethyl pyridine

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Diethyl-4-piperazinyl-2,6-pyridinedicarboxylate is dissolved in THF and treated with NaBH, and CaCl2 as per the procedure of Example 51 to give the title compound.

Sources & evidence

ORD record
ord-4c4d7719530649e58b56aaf45f965b29
Source dataset
uspto-grants-2001_12
Patent number
US06329523B1

Reaction notes

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