反应详情

温度

60 °C

Potassium carbonate (65.2 g) was added to a DMF solution (500 ml) of (2-formylphenyl)oxyacetonitrile (38 g), which was stirred at 60° C. for 2.5 hours. Water was added to the reaction mixture, which was extracted with diethyl ether. The organic layer was washed with water and a saturated aqueous sodium chloride solution, then dried and concentrated. The residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=10/1) to obtain the entitled compound (14.5 g).

1. extractionwas extracted with diethyl ether
2. washThe organic layer was washed with water
3. dry with materiala saturated aqueous sodium chloride solution, then dried
4. concentrationconcentrated
5. customThe residue was purified by silica gel column chromatography (eluent: hexane/ethyl acetate=10/1)