Hydrochloric Acid → 3-(2-Amino-benzo[d]phenyl)-2-methyl-2-propenoic acid

HRID 2269786Notes

Reaction equation

HRID 2269786 reaction equation
C([O:3][C:4](=[O:19])[C:5]([CH3:18])=[CH:6][C:7]1[CH:12]=[C:11]2[CH:13]=[CH:14][C:15]([NH2:17])=[CH:16][C:10]2=[CH:9][CH:8]=1)C.[OH-].[Na+].Cl>O1CCCC1>[NH2:17][C:15]1[CH:14]=[CH:13][C:11]2[C:10]([CH:16]=1)=[CH:9][CH:8]=[C:7]([CH:6]=[C:5]([CH3:18])[C:4]([OH:19])=[O:3])[CH:12]=2

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 702169223-(2-Amino-benzo[d]phenyl)-2-methyl-2-propenoic acid ethyl ester

Product 1

HCID 702145023-(2-Amino-benzo[d]phenyl)-2-methyl-2-propenoic acidYield 98%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Into 10 ml of tetrahydrofuran (THF), 0.65 g of (E) 3-(2-amino-benzo[d]phenyl)-2-methyl-2-propenoic acid ethyl ester was dissolved; and, with 10 ml of a 1-N aqueous sodium hydroxide solution being added thereto, the mixture was reacted for 4 hours at 40° C. After the completion of the reaction, the mixture was cooled with 10 ml of 1-N hydrochloric acid being added thereto, and the precipitated crystal was filtered out, whereby 0.57 g of the aimed compound was obtained (yield: 98%).

Workup

  1. customthe mixture was reacted for 4 hours at 40° C
  2. customAfter the completion of the reaction
  3. additionadded
  4. filtrationthe precipitated crystal was filtered out

Sources & evidence

ORD record
ord-b34ff908d6864fc486de33fb253deca0
Source dataset
uspto-grants-2001_12
Patent number
US06329546B1

Reaction notes

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