反应详情

Combine N,N′-dibenzyl-2-aminomalonamide trifluoroacetic acid salt (0.41 g, 1.04 mmol), (R)-2-bromo-3-phenylpropionic acid (0.262 g, 1.15 mmol), N-methylmorpholine (0.23 mL, 2.08 mmol), 1-ethyl-3-(3-(dimethylamino)propyl)carbodiimide hydrochloric acid salt (0.22 g, 1.15 mmol), and 1 -hydroxybenztriazole hydrate (0.155 g, 1.15 mmol) in dichloromethane (5 mL). After 18 hours, extract with an aqueous 5% sulfuric acid solution, a saturated sodium bicarbonate solution, and then brine. Dry the organic layer over Na2SO4, filter, and evaporate in vacuo to give a residue. Chromatograph the residue on silica gel eluting with 1/1 ethyl acetate/hexane to give the title compound.

1. extractionextract with an aqueous 5% sulfuric acid solution
2. dry with materialDry the organic layer over Na2SO4
3. filtrationfilter
4. customevaporate in vacuo
5. customto give a residue