Diethyl (ethoxymethylene)malonate → 2-[(5,6-Dimethyl-pyridin-2-ylamino)-methylene]-malonic acid diethyl ester
Reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([NH2:9])=[N:6][C:7]=1[CH3:8].[CH2:10]([O:12][C:13](=[O:24])[C:14](=[CH:20]OCC)[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH3:11]>>[CH2:10]([O:12][C:13](=[O:24])[C:14](=[CH:20][NH:9][C:5]1[CH:4]=[CH:3][C:2]([CH3:1])=[C:7]([CH3:8])[N:6]=1)[C:15]([O:17][CH2:18][CH3:19])=[O:16])[CH3:11]Participants
3
Procedure
Experimental conditions analogous to those described for Step 1 of Example 60 were used with 5 g (40.93 mmol) of 5,6-Dimethyl-pyridin-2-ylamine and 8.2 mL (40.93 mmol) of 2-ethoxymethylene malonic acid diethyl ester to afford 10.61 g of 2-[(5,6-Dimethyl-pyridin-2-ylamino)-methylene]-malonic acid diethyl ester.
Sources & evidence
- ORD record
- ord-8f66f8a7967c448f9564b0f6b850869b
- Source dataset
- uspto-grants-2009_07
- Patent number
- US07557213B2
Reaction notes
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