Diphenyl Ether → 3-(4-Methoxy-3-methyl-benzoyl)-1H-[1,5]naphthyridin-4-one
Reaction equation
CO[C:3](=[O:20])[C:4]([C:9](=[O:19])[C:10]1[CH:15]=[CH:14][C:13]([O:16][CH3:17])=[C:12]([CH3:18])[CH:11]=1)=[CH:5]OCC.[NH2:21][C:22]1[CH:23]=[N:24][CH:25]=[CH:26][CH:27]=1.C1(OC2C=CC=CC=2)C=CC=CC=1>>[CH3:17][O:16][C:13]1[CH:14]=[CH:15][C:10]([C:9]([C:4]2[C:3](=[O:20])[C:23]3[C:22](=[CH:27][CH:26]=[CH:25][N:24]=3)[NH:21][CH:5]=2)=[O:19])=[CH:11][C:12]=1[CH3:18]Participants
4
Procedure
Experimental conditions analogous to those described for Step 1 of Example 1 were used with 0.60 g (2.27 mmol) of 3-ethoxy-2-(4-methoxy-3-methyl-benzoyl)-acrylic acid methyl ester, 0.214 g (2.27 mmol) of 3-aminopyridine, and 15 mL of diphenyl ether to yield 0.435 g of 3-(4-Methoxy-3-methyl-benzoyl)-1H-[1,5]naphthyridin-4-one.
Sources & evidence
- ORD record
- ord-1e9595d483244754964d1cb99ea7ba57
- Source dataset
- uspto-grants-2009_07
- Patent number
- US07557213B2
Reaction notes
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