反应详情

Sodium hydride (3.82 g, 60% in mineral oil) was added to a solution of 7-methoxy-benzofuran-2-ylmethanol (11.21 g) in dry tetrahydrofuran (300 ml) under an atmosphere of dry nitrogen at room temperature. After 10 minutes iodomethane (15.67 ml) was added and the reaction was left to stir overnight. The solvent was removed in vacuo and the residue partitioned between ethyl acetate (100 ml) and water (50 ml). The organic extract was washed with water (50 ml), followed by brine (50 ml), dried over magnesium sulphate, filtered and the solvent removed in vacuo to afford the title compound (13.32 g) as a yellow oil.

1. waitthe reaction was left
2. customThe solvent was removed in vacuo
3. customthe residue partitioned between ethyl acetate (100 ml) and water (50 ml)
4. extractionThe organic extract
5. washwas washed with water (50 ml)
6. dry with materialdried over magnesium sulphate
7. filtrationfiltered
8. customthe solvent removed in vacuo