Triethylamine → HCID 22632898, compound

HRID 2270201Notes

Reaction equation

[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[CH3:13][O:14][C:15]1[CH:16]=[C:17]([N:21]2[C:30]3[C:25](=[CH:26][C:27]([F:32])=[C:28](F)[CH:29]=3)[C:24](=[O:33])[N:23]([O:34][CH2:35][C:36]3[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=3)[C:22]2=[O:42])[CH:18]=[CH:19][CH:20]=1>>[CH3:13][O:14][C:15]1[CH:16]=[C:17]([N:21]2[C:30]3[C:25](=[CH:26][C:27]([F:32])=[C:28]([N:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)[CH:29]=3)[C:24](=[O:33])[N:23]([O:34][CH2:35][C:36]3[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=3)[C:22]2=[O:42])[CH:18]=[CH:19][CH:20]=1

Participants

Reactant 3

HCID 8471Triethylamine

HCID 31268Pyrrolidine

HCID 22632893HCID 22632893, compound

Product 1

HCID 22632898HCID 22632898, compoundYield 86.7%

Procedure

Using General Method 4, the reaction of pyrrolidine (0.077 mL, 0.9 mmol), triethylamine (0.12 mL, 0.9 mmol), and 1-(3-methoxyphenyl)-3-benzyloxy-6,7-difluoro-1H-quinazoline-2,4-dione (Example E-1, 0.12 g, 0.3 mmol) provided 0.12 g of the title compound as a solid.

Sources & evidence

ORD record: ord-f9092a5aae584f9dbb85d9af4da19f88
Source dataset: uspto-grants-2001_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06331538B1

Reaction notes

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