Triethylamine → HCID 22632874, compound

HRID 2270204Notes

Reaction equation

[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.C(N(CC)CC)C.[F:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[C:31]2[C:26](=[CH:27][C:28]([F:33])=[C:29](F)[CH:30]=2)[C:25](=[O:34])[N:24]([O:35][CH2:36][C:37]2[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=2)[C:23]1=[O:43]>>[F:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][C:17]=1[N:22]1[C:31]2[C:26](=[CH:27][C:28]([F:33])=[C:29]([N:5]3[CH2:6][CH2:7][N:2]([CH3:1])[CH2:3][CH2:4]3)[CH:30]=2)[C:25](=[O:34])[N:24]([O:35][CH2:36][C:37]2[CH:38]=[CH:39][CH:40]=[CH:41][CH:42]=2)[C:23]1=[O:43]

Participants

Reactant 3

HCID 8471Triethylamine

HCID 531671-Methylpiperazine

HCID 22632993HCID 22632993, compound

Product 1

HCID 22632874HCID 22632874, compoundYield 100.3%

Procedure

Using General Method 4, the reaction of N-methylpiperazine (0.083 mL, 0.75 mmol), triethylamine (0.106 mL, 0.75 mmol), and 1-(2-fluorophenyl)-3-benzyloxy-6,7-difluoro-1H-quinazoline-2,4-dione (Example F-1, 0.1 g, 0.25 mmol) provided 0.12 g of the title compound as a solid.

Sources & evidence

ORD record: ord-58b44699796e461fa65e730099a82b5d
Source dataset: uspto-grants-2001_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06331538B1

Reaction notes

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