Triethylamine → HCID 22632992, compound

HRID 2270205Notes

Reaction equation

HRID 2270205 reaction equation
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.C(N(CC)CC)C.[F:13][C:14]1[CH:15]=[C:16]([N:20]2[C:29]3[C:24](=[CH:25][C:26]([F:31])=[C:27](F)[CH:28]=3)[C:23](=[O:32])[N:22]([O:33][CH2:34][C:35]3[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=3)[C:21]2=[O:41])[CH:17]=[CH:18][CH:19]=1>>[F:13][C:14]1[CH:15]=[C:16]([N:20]2[C:29]3[C:24](=[CH:25][C:26]([F:31])=[C:27]([N:1]4[CH2:5][CH2:4][CH2:3][CH2:2]4)[CH:28]=3)[C:23](=[O:32])[N:22]([O:33][CH2:34][C:35]3[CH:36]=[CH:37][CH:38]=[CH:39][CH:40]=3)[C:21]2=[O:41])[CH:17]=[CH:18][CH:19]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 31268PyrrolidineHCID 22632902HCID 22632902, compound

Product 1

HCID 22632992HCID 22632992, compoundYield 51.7%

Procedure

Using General Method 4, the reaction of pyrrolidine (0.1 mL, 1.28 mmol), triethylamine (0.18 mL, 1.28 mmol), and 1-(3-fluorophenyl)-3-benzyloxy-6,7-difluoro-1H-quinazoline-2,4-dione (Example G-1, 0.17 g, 0.43 mmol) provided 0.1 g of the title compound as a solid.

Sources & evidence

ORD record
ord-b142f8a0cf2a4bdd922387723593964e
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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