Triethylamine → HCID 22632900, compound

HRID 2270206Notes

Reaction equation

HRID 2270206 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH2:8](N(CC)CC)C.[F:15][C:16]1[CH:17]=[C:18]([N:22]2[C:31]3[C:26](=[CH:27][C:28]([F:33])=C(F)[CH:30]=3)[C:25](=[O:34])[N:24]([O:35][CH2:36][C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:23]2=[O:43])[CH:19]=[CH:20][CH:21]=1>>[F:15][C:16]1[CH:17]=[C:18]([N:22]2[C:31]3[C:26](=[CH:27][C:28]([F:33])=[C:1]([N:2]4[CH2:7][CH2:6][N:5]([CH3:8])[CH2:4][CH2:3]4)[CH:30]=3)[C:25](=[O:34])[N:24]([O:35][CH2:36][C:37]3[CH:42]=[CH:41][CH:40]=[CH:39][CH:38]=3)[C:23]2=[O:43])[CH:19]=[CH:20][CH:21]=1

Participants

4

Reactant 3

HCID 8471TriethylamineHCID 531671-MethylpiperazineHCID 22632902HCID 22632902, compound

Product 1

HCID 22632900HCID 22632900, compoundYield 91%

Procedure

Using General Method 4, the reaction of N-methylpiperazine (0.16 mL, 1.43 mmol), triethylamine (0.2 mL, 1.43 mmol), and 1-(3-fluorophenyl)-3-benzyloxy-6,7-difluoro-1H-quinazoline-2,4-dione (Example G-1, 0.19 g, 0.48 mmol) provided 0.209 g of the title compound as a solid.

Sources & evidence

ORD record
ord-59de148465d64ff88064b64b65bd7e0c
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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