HCID 22633028, compound → HCID 22632968, compound

HRID 2270288Notes

Reaction equation

HRID 2270288 reaction equation
C([O:8][N:9]1[C:14](=[O:15])[C:13]2[CH:16]=[C:17]([F:25])[C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[N:19][C:12]=2[N:11]([CH2:26][CH3:27])[C:10]1=[O:28])C1C=CC=CC=1>CO.C(OCC)(=O)C.[Pd]>[CH2:26]([N:11]1[C:12]2[N:19]=[C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)[C:17]([F:25])=[CH:16][C:13]=2[C:14](=[O:15])[N:9]([OH:8])[C:10]1=[O:28])[CH3:27]

Participants

5

Reactant 1

HCID 22633028HCID 22633028, compound

Product 1

HCID 22632968HCID 22632968, compound

Reagents, catalysts & solvents 3

HCID 23938PalladiumCatalystHCID 887MethanolSolventHCID 8857Ethyl AcetateSolvent

Procedure

Following the procedure of Example 32, hydrogenation of 3-benzyloxy-1-ethyl-6-fluoro-7-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidine-2,4-dione (Example X-2, 110 mg, 0.286 mmol) and 10% Pd/C (60 mg) in MeOH (2 mL) and ethyl acetate (3 mL) afforded 55 mg, of the title compound as a solid, mp 236-237° C. (decomp.).

Workup

  1. customafforded 55 mg

Sources & evidence

ORD record
ord-8d81348e12044135b467ed786cf22287
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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