HCID 22632931, compound → HCID 22633041, compound

HRID 2270299Notes

Reaction equation

HRID 2270299 reaction equation
C([O:8][N:9]1[C:14](=[O:15])[C:13]2[CH:16]=[C:17]([F:25])[C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[N:19][C:12]=2[N:11]([C:26]2[CH:31]=[CH:30][C:29]([F:32])=[CH:28][C:27]=2[F:33])[C:10]1=[O:34])C1C=CC=CC=1>C1COCC1.[Pd]>[F:33][C:27]1[CH:28]=[C:29]([F:32])[CH:30]=[CH:31][C:26]=1[N:11]1[C:12]2[N:19]=[C:18]([N:20]3[CH2:21][CH2:22][CH2:23][CH2:24]3)[C:17]([F:25])=[CH:16][C:13]=2[C:14](=[O:15])[N:9]([OH:8])[C:10]1=[O:34]

Participants

4

Reactant 1

HCID 22632931HCID 22632931, compound

Product 1

HCID 22633041HCID 22633041, compoundYield 48.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Using the method of Example 56, 20% Pd/C (40 mg), 3-benzyloxy-1-(2,4-difluorophenyl)-6-fluoro-7-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidine-2,4-dione (Example Q4, 0.15 g, 0.33 mmol) were combined in 50 mL of THF, to give 0.06 g of the title compound as a solid, mp 189-191° C.

Sources & evidence

ORD record
ord-485dc98ffa2844b2a1ed572b79448532
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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