HCID 22632999, compound → HCID 22633025, compound

HRID 2270301Notes

Reaction equation

HRID 2270301 reaction equation
C([O:8][N:9]1[C:14](=[O:15])[C:13]2[CH:16]=[C:17]([F:25])[C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[N:19][C:12]=2[N:11]([C:26]2[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:35])([F:34])[F:33])[CH:27]=2)[C:10]1=[O:36])C1C=CC=CC=1>C1COCC1.[Pd]>[F:25][C:17]1[C:18]([N:20]2[CH2:24][CH2:23][CH2:22][CH2:21]2)=[N:19][C:12]2[N:11]([C:26]3[CH:31]=[CH:30][CH:29]=[C:28]([C:32]([F:33])([F:34])[F:35])[CH:27]=3)[C:10](=[O:36])[N:9]([OH:8])[C:14](=[O:15])[C:13]=2[CH:16]=1

Participants

4

Reactant 1

HCID 22632999HCID 22632999, compound

Product 1

HCID 22633025HCID 22633025, compoundYield 57.3%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Using the method of Example 56, 20% Pd/C (25 mg), 3-benzyloxy-6-fluoro-7-pyrrolidin-1-yl-1-(3-trifluoromethylphenyl)-1H-pyrido[2,3-d]pyrimidine-2,4-dione (Example S-4, 0.17 g, 0.34 mmol) were combined in 25 mL of THF, to give 0.08 g of the title compound as a solid, mp 136-138° C.

Sources & evidence

ORD record
ord-95e6b8c337ee424e9e33fa22535c50c3
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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