HCID 22633008, compound → HCID 22632934, compound

HRID 2270302Notes

Reaction equation

HRID 2270302 reaction equation
C([O:8][N:9]1[C:14](=[O:15])[C:13]2[CH:16]=[C:17]([F:25])[C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)=[N:19][C:12]=2[N:11]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[F:32])[C:10]1=[O:33])C1C=CC=CC=1>C1COCC1.[Pd]>[F:32][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=1[N:11]1[C:12]2[N:19]=[C:18]([N:20]3[CH2:24][CH2:23][CH2:22][CH2:21]3)[C:17]([F:25])=[CH:16][C:13]=2[C:14](=[O:15])[N:9]([OH:8])[C:10]1=[O:33]

Participants

4

Reactant 1

HCID 22633008HCID 22633008, compound

Product 1

HCID 22632934HCID 22632934, compoundYield 116.4%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8028TetrahydrofuranSolvent

Procedure

Using the method of Example 56, 20% Pd/C (25 mg), 3-benzyloxy-1-(2-fluorophenyl)-6-fluoro-7-pyrrolidin-1-yl-1H-pyrido[2,3-d]pyrimidine-2,4dione (Example T-4, 0.14 g, 0.31 mmol) were combined in 25 mL of THF, to give 0.13 g of the title compound as a solid, mp >250° C.

Sources & evidence

ORD record
ord-122a32d6f4ce4dc2a9e3f31d87a459f5
Source dataset
uspto-grants-2001_12
Patent number
US06331538B1

Reaction notes

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