1-(2-Methoxyphenyl)piperazine → HCID 9890461, compound

HRID 2270438Notes

Reaction equation

HRID 2270438 reaction equation
Cl[CH2:2][CH2:3][CH2:4][CH2:5][N:6]1[CH:15]=[C:14]2[C:8]([C:9](=[O:19])[CH2:10][CH2:11][N:12]([CH3:18])[S:13]2(=[O:17])=[O:16])=[CH:7]1.[CH3:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][NH:31][CH2:30][CH2:29]1.C(=O)([O-])[O-].[K+].[K+].[I-].[Na+]>C(#N)C>[CH3:20][O:21][C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][C:23]=1[N:28]1[CH2:33][CH2:32][N:31]([CH2:2][CH2:3][CH2:4][CH2:5][N:6]2[CH:15]=[C:14]3[C:8]([C:9](=[O:19])[CH2:10][CH2:11][N:12]([CH3:18])[S:13]3(=[O:17])=[O:16])=[CH:7]2)[CH2:30][CH2:29]1

Participants

6

Reactant 4

HCID 13461-(2-Methoxyphenyl)piperazineHCID 5238Sodium IodideHCID 11430Potassium CarbonateHCID 22714956HCID 22714956, compound

Product 1

HCID 9890461HCID 9890461, compoundYield 99%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A suspension of 152 mg (0.5 mmol) of Compound 19, 144 mg (0.75 mmol) of 1-(2-methoxyphenyl)piperazine, 104 mg (0.75 mmol) of potassium carbonate and 150 mg (1 mmol) of sodium iodide in 20 ml of acetonitrile was refluxed for 17 hours. Post-treatment was conducted in a similar manner as in Example 18. The residue was purified by chromatography on a silica gel column (eluent:methanol/chloroform=1/19), whereby 160 mg of the title compound were obtained (yield: 99%).

Workup

  1. temperaturewas refluxed for 17 hours
  2. customThe residue was purified by chromatography on a silica gel column (eluent:methanol/chloroform=1/19)

Sources & evidence

ORD record
ord-5e7079f14e314b398d6217287c8861e0
Source dataset
uspto-grants-2001_12
Patent number
US06331623B1

Reaction notes

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