Benzo(B)Thiophene → 6314-41-6

HRID 2270673Notes

Reaction equation

HRID 2270673 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2.[Li]C(C)(C)C.[Cl:15][C:16]1[CH:23]=[CH:22][C:19]([CH:20]=[O:21])=[CH:18][CH:17]=1>C1COCC1>[S:1]1[C:5]([CH:20]([OH:21])[C:19]2[CH:22]=[CH:23][C:16]([Cl:15])=[CH:17][CH:18]=2)=[CH:4][C:3]2[CH:6]=[CH:7][CH:8]=[CH:9][C:2]1=2

Participants

5

Reactant 3

HCID 7221Benzo(B)ThiopheneHCID 77264-ChlorobenzaldehydeHCID 178418306HCID 178418306, compound

Product 1

HCID 2370726314-41-6

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

a-(2-benzo[b]thienyl)-4-chlorobenzyl alcohol was prepared by the method of Example 40A with benzo[b]thiophene (7.5 mmoles, 1.0 g), t-BuLi (1.7 m, 9.7 mmoles, 5.7 ml), 4-chlorobenzaldehyde (9.7 mmoles, 1.4 g) and THF (20 ml). The crude material (2.45 g) was taken forward without further purification.

Workup

  1. customThe crude material (2.45 g) was taken forward without further purification

Sources & evidence

ORD record
ord-195c0a4160f94e49bd70430192e1af87
Source dataset
uspto-grants-2001_12
Patent number
US06331637B1

Reaction notes

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