Hydrochloric Acid → HCID 18329725, compound

HRID 2270924Notes

Reaction equation

HRID 2270924 reaction equation
Cl.[Cl:2][C:3]1[C:4]([N:16]2[C:20]([C:21]3[CH:22]=[N+:23]([O-:27])[CH:24]=[CH:25][CH:26]=3)=[N:19][N:18]=[C:17]2[CH2:28][O:29][CH3:30])=[C:5]2[C:10](=[CH:11][C:12]=1[Cl:13])[NH:9][C:8](=[O:14])[C:7](=[O:15])[NH:6]2>CO>[OH2:14].[Cl:2][C:3]1[C:4]([N:16]2[C:20]([C:21]3[CH:22]=[N+:23]([O-:27])[CH:24]=[CH:25][CH:26]=3)=[N:19][N:18]=[C:17]2[CH2:28][O:29][CH3:30])=[C:5]2[C:10](=[CH:11][C:12]=1[Cl:13])[NH:9][C:8](=[O:14])[C:7](=[O:15])[NH:6]2

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 9867605UK-333747

Product 1

HCID 18329725HCID 18329725, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Concentrated hydrochloric acid (1 ml) was added to a stirred solution of (−)-6,7-dichloro-5-[3-methoxymethyl-5-(1-oxidopyridin-3-yl)-4H-1,2,4-triazol-4-yl]-2,3(1H,4H)-quinoxalinedione, silica complex (See Reference Example 1) (2.3 g, 4.64 mmol) in methanol (40 ml) and the mixture stirred for 2 hours. The solid precipitate was collected by filtration to afford the title compound as a white solid (1.4 g, 65%). mp 264-265° C.

Workup

  1. filtrationThe solid precipitate was collected by filtration

Sources & evidence

ORD record
ord-b83ec308c4c84b53bcecdf0908abf118
Source dataset
uspto-grants-2001_12
Patent number
US06333326B1

Reaction notes

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