Diethylamine → 1-(6-Bromo-pyridin-2-ylmethyl)-3-(6-diethylamino-pyridine-3-carbonyl)-1H-quinolin-4-one

HRID 227095Notes

Reaction equation

HRID 227095 reaction equation
[Br:1][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12](=[O:19])[C:11]([C:20]([C:22]3[CH:23]=[N:24][C:25](Cl)=[CH:26][CH:27]=3)=[O:21])=[CH:10]2)[CH:5]=[CH:4][CH:3]=1.[CH2:29]([NH:31][CH2:32][CH3:33])[CH3:30]>C1COCC1>[Br:1][C:2]1[N:7]=[C:6]([CH2:8][N:9]2[C:18]3[C:13](=[CH:14][CH:15]=[CH:16][CH:17]=3)[C:12](=[O:19])[C:11]([C:20]([C:22]3[CH:23]=[N:24][C:25]([N:31]([CH2:32][CH3:33])[CH2:29][CH3:30])=[CH:26][CH:27]=3)=[O:21])=[CH:10]2)[CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 8021DiethylamineHCID 57754507HCID 57754507, compound

Product 1

HCID 577547681-(6-Bromo-pyridin-2-ylmethyl)-3-(6-diethylamino-pyridine-3-carbonyl)-1H-quinolin-4-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Experimental conditions analogous to those described for Example 141, from 97 mg (0.21 mmol) of 1-(6-bromo-pyridin-2-ylmethyl)-3-(6-chloro-pyridine-3-carbonyl)-1H-quinolin-4-one and 3 mL diethylamine in 7 mL THF. Yield: 50 mg of a yellow powder. LC-MSD, m/z for C25H23BrN4O2 [M+H]+=491.0, 493.0; HPLC retention time: 2.9 min.

Sources & evidence

ORD record
ord-254f6667dba8489e925c90cf6ad5a0ca
Source dataset
uspto-grants-2009_07
Patent number
US07557213B2

Reaction notes

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