Chloroacetonitrile → HCID 18387782, compound

HRID 2271017Notes

Reaction equation

HRID 2271017 reaction equation
[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[CH:11]=[CH:10][C:9]([OH:12])=[CH:8][CH:7]=1.Cl[CH2:14][C:15]#[N:16].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C.O>[C:15]([CH2:14][O:12][C:9]1[CH:10]=[CH:11][C:6]([C:2]2[S:1][CH:5]=[CH:4][CH:3]=2)=[CH:7][CH:8]=1)#[N:16]

Participants

6

Reactant 3

HCID 7856ChloroacetonitrileHCID 11430Potassium CarbonateHCID 35641974-Thiophen-2-ylphenol

Product 1

HCID 18387782HCID 18387782, compoundYield 91.3%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

A mixture of 4-(2-thienyl)phenol (1.30 g), chloroacetonitrile (668 mg) and potassium carbonate (1.53 g) in DMF (7 ml) was stirred for 5 hours at ambient temperature. The mixture was diluted with H2O and the separated solid was recovered to give 1.45 g of 2-(4-cyanomethoxyphenyl)thiophene.

Workup

  1. customthe separated solid was recovered

Sources & evidence

ORD record
ord-e2aef15c43df4b78913552d20248578b
Source dataset
uspto-grants-2001_12
Patent number
US06333324B1

Reaction notes

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