反应详情

In 10 ml of benzene were stirred 1.01 g of N-chloroacetyl-N-(2-methoxybenzyl)-2-phenoxyaniline, 1.30 g of sodium acetate and 170 mg of tetra-n-butyl ammonium bromide at 80° C. for 5 hours. The reaction mixture was poured into ethyl acetate, washed with water and a saturated aqueous sodium chloride solution, successively, and dried over anhydrous sodium sulfate. After removal of the drying agent by filtration, the solvent was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent; ethyl acetate-hexane=1:3) to give 1.03 g of N-acetoxyacetyl-N-(2-methoxybenzyl)-2-phenoxyaniline as an oil.

1. washwashed with water
2. dry with materiala saturated aqueous sodium chloride solution, successively, and dried over anhydrous sodium sulfate
3. customAfter removal of the drying agent
4. filtrationby filtration
5. concentrationthe solvent was concentrated under reduced pressure
6. customthe residue was purified by silica gel column chromatography (eluent; ethyl acetate-hexane=1:3)