Benzaldehyde → HCID 11347883, compound

HRID 2271218Notes

Reaction equation

HRID 2271218 reaction equation
[OH:1][C:2]1[C:9]([C:10]([CH3:13])([CH3:12])[CH3:11])=[CH:8][C:7]([C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:6][C:3]=1[CH2:4][NH2:5].[CH:18](=O)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>CO>[CH:18](=[N:5][CH2:4][C:3]1[CH:6]=[C:7]([C:14]([CH3:17])([CH3:16])[CH3:15])[CH:8]=[C:9]([C:10]([CH3:11])([CH3:13])[CH3:12])[C:2]=1[OH:1])[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 12652148HCID 12652148, compound

Product 1

HCID 11347883HCID 11347883, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
-40 °C

Procedure

A solution of 2-hydroxy-3,5,di-t-butylbenzylamine (prepared by the procedure described by G. E. Stokker, et al.; J. Med. Chem. 1980, 23, 1414; 2.35 g, 10.0 mmol) is prepared in 50 mL methanol. Benzaldehyde (1.06 g, 10.0 mmol) is added, and the resulting solution is stirred for 30 minutes. Product crystallizes upon cooling the solution to −40° C.

Workup

  1. customProduct crystallizes

Sources & evidence

ORD record
ord-b1558e714da24b0182cb0ac7fa0ed0b4
Source dataset
uspto-grants-2001_12
Patent number
US06333389B1

Reaction notes

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