Acetate → Tetrahydrofuran isopropyl acetate

Compounds of formula I in free form and in single stereoisomeric form thus obtained may be converted into a salt by addition of an acid to the free base of a compound of formula I. E.g. a compound of formula I may be dissolved or suspended, or is obtained in dissolved or suspended form, in organic solvent, preferably a solvent or solvent mixture, such as an alcohol, e.g. methanol, ethanol; a halogenated hydrocarbon, e.g. dichloromethane; an ether, e.g. tetrahydrofuran, an acetate, such as methyl acetate, ethyl acetate, propyl acetate, isopropyl acetate; a solvent mixture of alcohol with acetate, such as methanol/isopropyl acetate, a solvent mixture of halogenated hydrocarbon with acetate, such as dichloromethane/isopropylacetate, a solvent mixture of ether with acetate, such as tetrahydrofuran/isopropyl acetate, and to the mixture obtained an acid, e.g. an organic acid or an inorganic (mineral) acid, e.g. acetic acid, lactic acid, e.g. L-lactic acid, maleic acid, is added. A compound of formula I, in the form of a salt, e.g. crystalline salt, may be obtained and may be isolated.

1. customCompounds of formula I in free form and in single stereoisomeric form thus obtained may
2. additionbe converted into a salt by addition of an acid to the free base of a compound of formula I
3. dissolutionE.g. a compound of formula I may be dissolved
4. customis obtained
5. dissolutionin dissolved

ORD record

ord-ce4439f8ff9245c884c3403f8846569b

Source dataset

uspto-grants-2015_09

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US09120727B2