Hydrochloric Acid → HCID 70676330, compound

HRID 2271497Notes

Reaction equation

HRID 2271497 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH:10]([O:22][C:23]2[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=2)[CH:11]2[CH2:14][N:13](C(OC(C)(C)C)=O)[CH2:12]2)[CH:6]=[CH:7][C:8]=1[Cl:9]>CO>[ClH:2].[Cl:2][C:3]1[CH:4]=[C:5]([CH:10]([O:22][C:23]2[CH:24]=[CH:25][CH:26]=[CH:27][CH:28]=2)[CH:11]2[CH2:14][NH:13][CH2:12]2)[CH:6]=[CH:7][C:8]=1[Cl:9]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 70676150HCID 70676150, compound

Product 1

HCID 70676330HCID 70676330, compoundYield 97%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
60 °C

Procedure

1N HCl (3 mL) was added to 10 mL of tertiary butyl 3-((3,4-dichlorophenyl)(phenoxy)methyl)azetidine-1-carboxylate (150 mg, 0.352 mmol) dissolved in a methanol solution, and heated to reflux at 60° C. for one day. Thereafter, the solvent of the reaction mixture was removed by reduced pressure evaporation to obtain the title compound.

Workup

  1. temperatureheated
  2. customThereafter, the solvent of the reaction mixture was removed by reduced pressure evaporation

Sources & evidence

ORD record
ord-93bc20a08d9041a0b7ad8d0f4530eab1
Source dataset
uspto-grants-2015_09
Patent number
US09120771B2

Reaction notes

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