Hydrochloric Acid → HCID 86722613, compound

HRID 2271501Notes

Reaction equation

HRID 2271501 reaction equation
Cl.[Cl:2][C:3]1[CH:4]=[C:5]([CH:10]([CH:16]2[CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17]2)CS(C)(=O)=O)[CH:6]=[CH:7][C:8]=1[Cl:9].[CH3:27][OH:28]>>[ClH:2].[CH:27]1([O:28][CH:10]([C:5]2[CH:6]=[CH:7][C:8]([Cl:9])=[C:3]([Cl:2])[CH:4]=2)[CH:16]2[CH2:17][NH:18][CH2:19]2)[CH2:7][CH2:8][CH2:3][CH2:4]1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 887MethanolHCID 86722612HCID 86722612, compound

Product 1

HCID 86722613HCID 86722613, compoundYield 97%

Conditions

Temperature
60 °C

Procedure

1 N HCl (3.0 mL) was added to 10 mL of tertiary butyl 3-(1-(3,4-dichlorophenyl)-2-(methylsulfonyl)ethyl)azetidine-1-carboxylate (0.15 g, 0.36 mmol) dissolved in the methanol solution and heated to reflux at 60° C. for one day. Thereafter, the solvent of the reaction mixture was removed by reduced pressure evaporation to obtain the title compound.

Workup

  1. temperatureheated
  2. customThereafter, the solvent of the reaction mixture was removed by reduced pressure evaporation

Sources & evidence

ORD record
ord-b84ee1e4de4942dd8cd64db1e509e761
Source dataset
uspto-grants-2015_09
Patent number
US09120771B2

Reaction notes

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