反应详情

To a solution of ethyl (1E)-N-hydroxyethanimidate (8.4 g, 81.5 mmol) in DMF (20 mL) is added triethylamine (12 mL, 86.24 mmol) and the mixture is stirred for 20 minutes. 2,4,6-Trimethylbenzene-1-sulfonyl chloride (20 g, 81.5 mmol) is added and the reaction mixture is stirred at room temperature for 16 hours. The reaction mixture is quenched with water (100 mL) and extracted with EtOAc (3×100 mL). The combined organic extracts are dried over sodium sulphate, filtered, and evaporated to dryness to give the title compound as white solid (15 g, 64%). The crude material is used without further purification.

1. stirringthe reaction mixture is stirred at room temperature for 16 hours
2. customThe reaction mixture is quenched with water (100 mL)
3. extractionextracted with EtOAc (3×100 mL)
4. dry with materialThe combined organic extracts are dried over sodium sulphate
5. filtrationfiltered
6. customevaporated to dryness