反应详情

0.60 g (3.5 mmole) anhydrous tosylic acid was dissolved in possibly as little as ethanol. Then a solution of 0.55 g (0.38 mmole) N-(1-methylethyl)-2,3-dimethyl-2-butylamine in 10 mL anhydrous ether was added dropwise with stirring. The mixture was stood overnight, and then distilled off the solvent. The residue was washed thoroughly with anhydrous ethanol to give a colorless solid 1.07 g, mp 119-120° C. 1H-NMR(D2O, ppm) 0.96(d, 6H, 2CH3), 1.303(s, 6H, 2CH3), 1.36(d, 6H, 2CH3), 2.02-2.15(m, 1H, C(H), 2.401(s, 3H, CH3), 3.62-3.73(m, 1H, CH), 7.38(d,2H, 2Ar—H), 7.70(d,2H, 2Ar—H).

1. distillationdistilled off the solvent
2. washThe residue was washed thoroughly with anhydrous ethanol