Pyridine → HCID 117831258, compound

HRID 2272861Notes

Reaction equation

HRID 2272861 reaction equation
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[Br:7][CH2:8][C:9]([OH:11])=[O:10]>C(OCC)(=O)C>[Br-:7].[C:9]([CH2:8][NH+:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH2:2]1)([OH:11])=[O:10]

Participants

4

Reactant 2

HCID 1049PyridineHCID 6227Bromoacetic Acid

Product 1

HCID 117831258HCID 117831258, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 16.2 mL of pyridine (200 mmol) in 120 mL of ethyl acetate there are added in portions 27.8 g (200 mmol) of bromoacetic acid. The whole is subsequently stirred at ambient temperature overnight. The precipitate so obtained is filtered off and then washed with cold ethyl acetate. After drying, the title product is obtained in the form of a powder, which is used directly for the following step.

Workup

  1. customThe precipitate so obtained
  2. filtrationis filtered off
  3. washwashed with cold ethyl acetate
  4. customAfter drying

Sources & evidence

ORD record
ord-bf4663b0b17747968e84b378692dd6ec
Source dataset
uspto-grants-2015_09
Patent number
US09120791B2

Reaction notes

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