Dichloromethane → 8-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-(4-morpholin-4-yl-phenyl)-amine

HRID 2272993Notes

Reaction equation

HRID 2272993 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([C:7]2[CH:12]=[CH:11][C:10]([N:13]=[C:14]=S)=[CH:9][CH:8]=2)[CH2:3][CH2:2]1.C1(C([O-])=O)C=C(C)C=C(C)C=1.[NH2:27][N+:28]1[CH:33]=[CH:32][N:31]=[CH:30][C:29]=1[NH2:34].C(N(C(C)C)CC)(C)C.CCN=C=NCCCN(C)C.[Cl:55]CCl>>[Cl:55][C:30]1[C:29]2[N:28]([N:27]=[C:14]([NH:13][C:10]3[CH:11]=[CH:12][C:7]([N:4]4[CH2:5][CH2:6][O:1][CH2:2][CH2:3]4)=[CH:8][CH:9]=3)[N:34]=2)[CH:33]=[CH:32][N:31]=1

Participants

6

Reactant 5

HCID 6344DichloromethaneHCID 159081-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 81531DiisopropylethylamineHCID 2248624-(4-Isothiocyanatophenyl)morpholineHCID 1317328011,2-Diamino-pyrazinium mesitylenate

Product 1

HCID 866943398-Chloro-[1,2,4]triazolo[1,5-a]pyrazin-2-yl-(4-morpholin-4-yl-phenyl)-amineYield 84.17%

Procedure

To a solution of 4-morpholinophenylisothiocyanate (2 g, 8.99 mmol) in dry dichloromethane (200 ml), 1,2-diamino-pyrazinium mesitylenate (3.86 g, 11.24 mmol), diisopropylethylamine (5.81 g, 44.99 mmol) and EDCI (3.44 g, 17.98 mmol) are added and stirred for 6 hours. The reaction mixture is concentrated and the residue is taken in water (100 ml), triturated and filtered, washed with water (50 ml×2) and dried, the crude solid is purified by silica column using (60-120) mesh to get the titled product as light brown solid (2.5 g, 84.17%); TLC: chloroform/methanol (9.5/0.5) Rf—0.3; HPLC puritiy (method A) 98%; Rt (min): 2.21; LCMS: mass found (M+, 331.0), Rt (min): 2.08;

Workup

  1. concentrationThe reaction mixture is concentrated
  2. customtriturated
  3. filtrationfiltered
  4. washwashed with water (50 ml×2)
  5. customdried
  6. customthe crude solid is purified by silica column

Sources & evidence

ORD record
ord-740e9b2a9ee3495194cb3e90a088eadc
Source dataset
uspto-grants-2015_09
Patent number
US09120804B2

Reaction notes

Loading…