Lithium Hydroxide → HCID 86731622, compound

HRID 2273105Notes

Reaction equation

[F:1][C@@H:2]1[CH2:6][N:5]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:16])[F:15])[CH:9]=2)[C@@H:4]([C:18]([O:20]CC2C=CC=C(C(F)(F)F)C=2)=[O:19])[CH2:3]1.[Li+:32].[OH-]>>[F:1][C@@H:2]1[CH2:6][N:5]([CH2:7][C:8]2[CH:13]=[CH:12][CH:11]=[C:10]([C:14]([F:17])([F:15])[F:16])[CH:9]=2)[C@@H:4]([C:18]([O-:20])=[O:19])[CH2:3]1.[Li+:32]

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 86731618HCID 86731618, compound

Product 1

HCID 86731622HCID 86731622, compound

Procedure

The title compound (D16) (60 mg) was prepared according to the general procedure for esters hydrolysis starting from (2R,4S)-3-(trifluoromethyl)benzyl 4-fluoro-1-(4-(trifluoromethyl)benzyl)pyrrolidine-2-carboxylate (D9) (110 mg). (LiOH: 2 eq; Reaction time: 18 hrs)

Sources & evidence

ORD record: ord-56a022307b49439f92dd42aecbef4072
Source dataset: uspto-grants-2015_09
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US09120824B2

Reaction notes

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